posted about 23 hours ago on metafilter
My boyfriend is legally blind. He was born with cataracts in both eyes and has moderate to severe astigmatism in one of them. I'm struggling to get some idea of what he sees.Some background: He had a few cataract surgeries as a child (late 60's and early 70's). He says were ineffective or botched. I'm not sure if the astigmatism was always there or if it was developed later. He walks to work or takes the subway/street car. If we're walking together I'll warn him about dips or elevated bits of sidewalks under my breath (up, pothole at your 2, etc), but otherwise, he's okay on his own. He can read if the font is big enough and the material is close to his face. We've been to a couple different eye doctors and were told that the combination of the cataracts and astigmatism made surgery not an option. If anyone has some insight on that, I'd be interested as well. Basically, I'd love to have a better idea of what/how he sees. I ask him every now and then, "Can you see that?", which can give me a frame of reference, but it's not the most fun question for him. Since he's had this problem since birth it's hard for him to describe what he's seeing. Everything has always been blurry. I guess what I'm looking for is some sort of cataract + astigmatism simulator? What might the combination of those two conditions look like? Thanks in advance and my apologies if this is really disjointed.

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posted about 23 hours ago on metafilter
Pharrell Loves My Work Anne Marsen compares the video of Girl Walk//All Day with Pharrell's Happy

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posted 1 day ago on metafilter
Bacterial diseases cause millions of deaths every year. Most of these bacteria were benign at some point in their evolutionary past, and we don't always understand what turned them into disease-causing pathogens. In a new study, researchers have tracked down when this switch happened in one flesh-eating bacteria. They think the knowledge might help predict future epidemics. Nassera W, Beresa SB, Olsen RJ et al. 2014. Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences. PNAS. doi: 10.1073/pnas.1403138111 We sequenced the genomes of 3,615 strains of serotype Emm protein 1 (M1) group A Streptococcus to unravel the nature and timing of molecular events contributing to the emergence, dissemination, and genetic diversification of an unusually virulent clone that now causes epidemic human infections worldwide. We discovered that the contemporary epidemic clone emerged in stepwise fashion from a precursor cell that first contained the phage encoding an extracellular DNase virulence factor (streptococcal DNase D2, SdaD2) and subsequently acquired the phage encoding the SpeA1 variant of the streptococcal pyrogenic exotoxin A superantigen. The SpeA2 toxin variant evolved from SpeA1 by a single-nucleotide change in the M1 progenitor strain before acquisition by horizontal gene transfer of a large chromosomal region encoding secreted toxins NAD+-glycohydrolase and streptolysin O. Acquisition of this 36-kb region in the early 1980s into just one cell containing the phage-encoded sdaD2 and speA2 genes was the final major molecular event preceding the emergence and rapid intercontinental spread of the contemporary epidemic clone. Thus, we resolve a decades-old controversy about the type and sequence of genomic alterations that produced this explosive epidemic. Analysis of comprehensive, population-based contemporary invasive strains from seven countries identified strong patterns of temporal population structure. Compared with a preepidemic reference strain, the contemporary clone is significantly more virulent in nonhuman primate models of pharyngitis and necrotizing fasciitis. A key finding is that the molecular evolutionary events transpiring in just one bacterial cell ultimately have produced millions of human infections worldwide. Significance Epidemics of microbial infections are a considerable threat to human and animal health. Analysis of 3,615 genome sequences, coupled with virulence studies in animals, permitted us to delineate the nature and timing of molecular events that contributed to an ongoing global human epidemic of infections caused by group A Streptococcus, the "flesh-eating" pathogen. We clarified decades-long uncertainty about the timing and sequence of genomic alterations that underpinned the global epidemic. Analyses of this type are crucial for developing better strategies to predict and monitor strain emergence and epidemics, formulate effective protective public health maneuvers, and develop or modify vaccines.

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posted 1 day ago on metafilter
History of the Cycle World Record brought to you by the World Sport Stacking Association. [previously] see also Sport Stacking 2013: A Year in Review for more sport stacking history being made.

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posted 1 day ago on metafilter
How many rappers have name-checked Tough Actin' Tinactin brand anti-fungal skin products? More than you would think.

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posted 1 day ago on metafilter
(asking on behalf of a friend) I'm thinking about using the ADA regulations to try to move from night shift to day shift. How would this work?About 2 years ago, I was diagnosed with bipolar disorder and 6 months ago I took a night shift position in a veterinary lab. Working the night shift is aggravating my depression and it's making it really hard just to function on a daily basis. My job also has 1st and 2nd shift positions, but they're full right now. I really love my job except for third shift stuff, and I don't want to quit. I'm wondering if anybody knows about the ADA process and whether this is considered a "reasonable accommodation". How do I go about requesting that they move me to first shift?

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posted 1 day ago on metafilter
How do I deal with completely different ideals in a marriage?I grew up lower-middle class in Mexico. I've always known what I want out of life, and I've worked hard to get to where I wanted to be. I have a strong work ethic, and I attempt to find satisfaction in any task I am given, no matter how unpleasant. My husband grew up in an upper middle class household. When we married, he held strong anarcho-communist ideals and this dissatisfaction with society has followed him since. He struggles with the thought of working meaningless jobs to make someone else richer, the thought of work fueling life rather than the other way around. If it was up to him, he'd live in a society where everyone works in what they're skilled in to their best of their ability. However, and unfortunately for him, we don't live in the society that he wishes to live in. This disparity makes him angry and generally unsatisfied with life. I do not necessarily agree with his worldview, but I respect it. He doesn't seem to agree with my work ethic; he finds it sad that I'm essentially a happy slave of society. He says that he's "angry on my behalf". When we married, he didn't know what he wanted to do with life. We decided that I would work and study while he found out what he enjoyed in life, something he could hopefully make a career out of. He flipflopped around a few majors in college, and eventually found applied math, which he enjoys. He is almost done with his degree, and he's found work within his college as a lab monitor. However, with college ending and the "real world" fast approaching, we've tried to hold conversations discussing jobs and such. And he's started to say things like his ideal job is one that doesn't make him want to kill himself, or that he wants to find a manual work that exhausts him enough that he has no time to think, or a job where he has to do next to nothing (similar to what he has at the moment). I'm alarmed at these thoughts, and suggested counseling. He will not go to counseling, and when I asked him to tell me why, he linked me to this article. He also said that he thinks there's nothing wrong with the way he thinks, and likes himself just the way he is. Eventually, he just said that he wants me to carry on with my goals and dreams, and he'll just be along for the ride. One past argument had him telling me that he would get a job and do everything I wanted him to do, pretend to enjoy his life and work, and once we were old and grey he would tell me it was all a farce. While these were words said in anger, they still come up in my thoughts often. I don't want to force him to work along with my goals. That's a horrible life to lead! If he finds no joy in his work, and I'm forcing him to do something he truly doesn't want to do, that'll only lead him to resent me. I'm currently in therapy and medication for anxiety. My therapist's take in it is that life is taking us in separate paths, and I need to consider separation. But that seems like giving up. He's a kind, loving man. I want nothing more than to see him happy; if I didn't, I would just carry on and let him follow. What do I do? How do I come to terms with this seemingly massive rift?

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posted 1 day ago on metafilter
Cartoonist Lisa Hanawalt shadows chef Wylie Dufresne for a day.

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posted 1 day ago on metafilter
I have been unable to turn up a list of the artists included in this book. I've tried Google Books, Amazon, and the publisher's own website. None of my local stores or libraries have it available. Can anyone tell me which artists are included in this book? I realize it's a really long list, but maybe the table of contents are out there somewhere, scanned or otherwise. Thanks!

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posted 1 day ago on metafilter
We'd like to move to another city for family reasons, but it will likely require a step back for me career-wise. I'd like to hear about how that worked out for other people. Can you help me get excited about it?I work in a quasi-academic field and have been reasonably happy and pretty successful at my job. The majority of my job is managerial/administrative at this point, but I also have an academic appointment and spend part of my time teaching graduate students, which I enjoy a lot. I also do some scholarly work, although the projects are small and largely specific to the institution (something like curriculum evaluation). I don't have supported time for teaching and research at the moment, but they are possible due to my current role, which means my schedule is relatively flexible and I can make time for lectures and research-related meetings during the day as long as my other work gets done. We live in an expensive city. My spouse and I have been thinking about relocating back to Spouse's home city, and I've done some preliminary job searching and identified a couple of possible jobs. It is very likely that I will be offered at least one of these jobs should I want to pursue it. Spouse would likely continue working for their current employer and telecommute. We have young kids. I provide about 70% of our income. The pros: -I would make the same or slightly less money than I do now, which would effectively be a raise given the substantial cost of living difference between the two cities. -Spouse's family (who I like) and some friends would be local. -Good public schools -Much shorter commute would mean more time with kids -There would probably be eventual avenues for promotion after a few years in the new job. The cons: -There are only a couple of potential employers for me in spouse's home city, and it's looking like making the move will require some loss of seniority on my part. I would basically be going back to the first job I had after finishing my graduate work six years ago. -With that would come a substantial increase in time spent doing a particular key function that is OK but not really something I love doing. Also a lot less schedule flexibility and thus less time to teach and do research, which will be necessary for academic promotion. -I would need to start over with building a professional network, and the more rigid schedule would make it difficult to get involved in research or teaching. I think I would also be at a disadvantage for academic promotion because a lot of my accomplishments thus far are specific to my current institution and, while my current employer appreciates them and they would "count" toward promotion requirements, they may not be as interesting to a new place. I feel like I've just gotten to the point where those things are going well for me, and I'm not sure I have the energy to do it all over again. -I started graduate school in my late 20s and so part of me feels like I'd be even further behind where I "should" be (currently in my early 40s). I feel like making the move is probably the right thing to do for my family, but I'm having a tough time getting excited about it. I can't decide how much is just being comfortable in my current role and how much is genuine lack of enthusiasm about the available jobs. On the other hand, it will only get harder to go back to an entry-level job, so maybe I should just bite the bullet. I feel like there are a lot of relocation questions on Metafilter but that most people move for lateral positions or promotions. I'd love to hear from people who have taken a step backward in their careers in exchange for lifestyle even though they're ambitious, or who have decided against doing that.

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posted 1 day ago on metafilter
I've decided that I want to get a few graphic t-shirts for the summer. I've found a few designs on Spreadshirt that I like, but I've never used the service before, and I'm sort of nervous about their general quality. Overall I'm wondering if anyone has experience buying from them. If not, then do you have experience buying from other store-fronts that sell custom printed shirts from a broad range of artists? I'm looking for a wide range of designers, and as few clever puns or of-the-moment pop culture references as possible. I'm interested in abstract designs more than stuff that's text or brand heavy. Ideally this would be about 20 dollars per shirt.

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posted 1 day ago on metafilter
Sketchy, potentially scammy situation with my brother traveling in Guatemala and requesting my phone info to transfer money over Paypal. What to do?My brother just emailed from Guatemala, where he's traveling, saying his iPhone was stolen and his debit card is lost. He said that he borrowed money from someone and needs to Paypal them the money back, but needs to confirm his account. He asked if he could use my phone to text the Paypal confirmation to. My scam radar went up, so I asked him if he knew my dog's name, which he correctly provided. He also added personal information that only he would know. I agreed to give him my cell phone number, but then he also wanted the address on my cell phone bills. This whole situation feels very strange and I don't feel comfortable with it. He just emailed my mom with the same request (I couldn't respond for an hour or so, so presumably he turned to other family members). Am I right to be concerned about a scam? I'm also worried about the worst case scenario, that Guatemalan thieves have him at gunpoint somewhere, and that I can't know whether that's the case.

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posted 1 day ago on metafilter
Help me, Metafilter! Which episode of Seinfeld is this animated GIF from?

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posted 1 day ago on metafilter
Won't you please, please won't you be my neighbor? NASA's Kepler Discovers First Earth-Size Planet In The 'Habitable Zone' of Another Star. Kepler-186f is a planet about ten percent bigger than Earth that orbits within the habitable zone of its star. The light there is dim and orange, and it only gets about a third of the sunshine we do, but that may be enough for life. If you go outside tonight, there might be someone 500 light years away looking back at you...

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posted 1 day ago on metafilter
Asides from the Jamaican bobsled team, which other international competitors or talents are involved in pursuits that seem like a highly unlikely match given their nationality or location?Sports would probably be an easy match (say, a Malaysian ice-skating champion), but there might be other avenues too, such as arts and culture (e.g. a Korean world-class flamenco dancer).

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posted 1 day ago on metafilter
High End Customizable Sauna Experience by Porpentine

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posted 1 day ago on metafilter
What is "The storm cannot be stopped; but it can be survived" in Latin?

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posted 1 day ago on metafilter
How Americans Die - a visual tour through surprising trends in mortality among Americans in the last several decades

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posted 1 day ago on metafilter
Yupanqui's gorgeous and meaningful songs have been covered by musicians, worldwide. Yupanqui's are songs about life, revolution, the worker, and everyday things (like a workers cart). Give a listen to some of his songs (and their covers) - even if you don't understand a word of Spanish, you will be rewarded lilting melody and the soul of a true musician/poet. Unfortunately, Yupanqui's work is little known in America, yet his music was very popular in Europe and Latin America, where his albums sold into the 10's of millions. I hope this will help expose more people to his music. Many the songs listed below are sung by Yupanqui, and also covered by others. Enjoy. Los Ejes de mi carreta (Yupanqui) Los Ejes de mi Carreta sung by Yupanqui, live Le Tengo Rabia del Silencio (Yupanqui) (Yupanqui, again) also sung by: Maria LeForet Bastian Saez Dercio Marquez Nada Mas (Yupanqui) Hay Leña Que Arde Sin Humo/El Carrero/ Ave Que Pasas Cantado /Los Yuyitos Sin Caballo y en Montiel (Yupanqui) also, sung by: Miguel Zurdo Martinez Piedra y Camino (Yupanqui) also, sung by: Piedra y Camino (Mercedes Sosa) Baglietto y Vitale Luna Tucumana (Yupanqui) Luna Tucumana (Yupanqui) El Poeta (Yupanqui) also, sung by: Jorge Cafrune Preguntitas sobre dios (Yupanqui) also, sung by: Preguntitas sobre dios (Chavela Vargas) Preguntitas sobre dios (Victor Jara) Duerme Negrito (Yupanqui) also, sung by: Duerme Negrito (Mercedes Sosa) Duerme Negrito (Victor Jara) Duerme Negrito (Tania Libertad) Los Hermanos (Yupanqui) also, sung by: Los Hermanos (Diego el Cigala, with Andres Calamaro) Los Hermanos (Mercedes Sosa) Los Hermanos (Mercedes Sosa, again) Pedro Anzar Bïa et Lhasa de Sela El Alazan (Yupanqui) El Alazan (Yupanqui, again) also, sung by: El Alazan (Voces Del Viento) El Alazan (Suma Paz) El Alazan (arr. Hugo de la Vega) Caminito del Indio also, sung by: Hector Belaustegui Chacarera de las Piedras (Yupanqui) Chacarera de las Piedras (Yupanqui, in an early film) also, sung by: Carlos Di Fulvio Recuerdos del Portezuelo (Yupanqui) also, sung by: Cuerda y Voz Daniel Viglietti Indiecito dormido (Yupanqui) also, sung by: Rosa Maria Lobo El Aromo (Yupanqui/ wr.Risso) also, sung by: unknown unknown#2 Milonga del Solitario (Yupanqui, instrumental lead in, voice) Zamba del Grillo (Yupanqui, instrumental) La Pura Verdad (Yupanqui, instrumental) El Arriero (Yupanqui) Milonga del Peon del Campo (Yupanqui) also, sung by: Milonga del Peon del Campo (Alberto Merlo) Jorge Cafrune La añera (Yupanqui) also, sung by: La añera (Pedro Aznar) La añera (Chango Nieto) La añera (El Sosias) Tu Que Puedes, Vuelvete (Yupanqui) also, sung by: Maria Dolores Padrera Mercedes Sosa Cancion Para Pablo Neruda, a song/poem dedicated to Pablo Neruda (Yupanqui) Cancion Para Pablo Neruda, again Yupanqui's Discography Habla de la solidaridad (interview with Yupanqui, in Spanish)

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posted 1 day ago on metafilter
This summer, I'll be deciding whether I'll be continuing with college, or if I want to leave and go into the real world and learn on my own. So I want to see the real world and get some perspective. What trips have you guys done that have been really eye-opening and meaningful?I actually did a round-the-world trip about a year ago, and recently enrolled back in college after dropping out for a few years. But I haven't really seen much of the world outside of the library and my apartment, which has been really frustrating. I'd like to get that worldly perspective once more—so I'm curious where you guys have gone that really meant a lot to you.

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posted 1 day ago on metafilter
I am a feminist, and many (not all) of my colleagues routinely make sexist comments. They know I am not okay with this, and instead of holding back, they now often do it even more blatantly, partly to get a rise out of me. I'm something of a beginner feminist so I don't know what to do. Tips please?My workplace is a combination of two of the most entrenched sectors of overwhelmingly male staff in the modern world. There is, as you may guess, a very strong boys' club mentality. I've objected strongly to a number of the comments in the hope that it would do some good, but instead what has happened is that the people who make them have just escalated - now they are said very deliberately in my direction. Since my female colleagues work down the hall and are almost never in the room I'm in, it hasn't actually happened in front of them that I've seen, and I don't know if it would - but that shouldn't matter. A general illustration of the kind of comments - explicitly stating [referring to a female colleague] that appearance is her primary asset, general things about women not being as good in any number of things including the field in which we work, rape apology, rape/harassment/stalking jokes and plenty of other stuff besides. Please note that when I've been able to get any kind of serious discussion going (though this has only happened with a couple of the people concerned), they are quite ready to speak of women equally and listen to points about what causes the dearth of applications to work in our field, and plenty of other issues relevant to equal rights. This post is about the majority of the time when they just want to joke around and find an easy route to doing so in throwing off these kinds of comments - and yes, I've already pointed out that it is part of the problem, and they laughed it off. Part of the problem is that I'm not comfortable taking this to my immediate boss because although he's pretty good in comparison, he still leans that way a little bit and I'm not confident he would see it as a problem. I'm also worried about what would happen if I found an appropriate person to take it to - this is something the majority of my closest colleagues do, and I would expect them to feel aggrieved if I made an issue about something they consider 'just banter'. Finally, I'm also desperately bad at confrontation, regardless of what it's about - my natural inclination would just have been to refuse to take part but I know that's not enough. I don't want to consider leaving - this job is solid gold for my career in a dozen different ways, but the most ethically sound course of action I have come up with so far seems to involve taking a flying leap at this mental barrier AND most likely alienating myself in the process. What alternatives do I have? NB: the people involved include both my peers and a couple of people who are senior to me; although they are NOT in charge of me, they do have some influence such as input into my performance reviews and being some of the primary sources of on the job learning.

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posted 1 day ago on metafilter
What device is to writing what the Kindle is for reading? Assume a Kindle is, for purposes of this question, electronic, single-purpose, efficiently designed, portable, small and stylish -- and not a tablet like an iPad or Nexus. The method of document storage does not matter.

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posted 1 day ago on metafilter
ALT/1977 is a series of advertising mock-ups which imagines modern products with the aesthetics and production of 1970s consumer electronics. Faux-wood paneling, angular fonts, and more orange than you can shake a stick at.

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posted 1 day ago on metafilter
When his parents went out of town, 16 year old Corey Worthington threw a party. When 500 people showed up, things got out of hand. Eventually the police were called, who mobilized units including their air wing & canine teams to quell the disturbance (for which Corey is being billed $20,000). And in the aftermath, Corey gave this awesome interview.

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posted 1 day ago on metafilter
"This is specifically challenging in science fiction and fantasy, where there are often so many ways to heal someone–from super-science to ancient sorcery. And yet there are issues with miracle cures in fiction. For one thing, they rob disability of its narrative power. For another, they play into the problematic narrative that people with a disability somehow "deserve" it." -- Elizabeth Bear talks about writing characters with disabilities in science fiction and fantasy in a guest post for Sarah Chorn's Special Needs in Strange Worlds column. In this SF Signal column, Sarah Chorn explores how fantasy and science fiction treat disability, through reading lists, author interviews and the examination of characters with disabilities like Tyrion Lannister.

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